Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Autoregulation of Blood Flow

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Calretinin and Parvalbumin Trapping of TDP43 and XRCC1 Instructs Neocortical Interneuron Death in Neonatal Hypoxic-Ischemic Encephalopathy.

Biomolecules·2026

Same author

Heme Iron Polypeptide Resolves Iron-deficiency Anemia in Rats and Mice.

Biological trace element research·2026

Same author

Prominent astrocytic GLAST pathology occurs in newborn human and piglet hypoxic-ischemic encephalopathy: modeling relationships among laminar neuropathology, seizures, and therapeutic hypothermia.

Frontiers in cellular neuroscience·2026

Same author

Proceedings of the 2024 FDA-CRCG Workshop: Scientific and Regulatory Considerations for Assessment of Immunogenicity Risk for Generic Peptide and Oligonucleotide Drug Products.

The AAPS journal·2026

Same author

Developing a Multivariable Prediction Model to Identify a High-Volume Patent Ductus Arteriosus in Neonates Born Extremely Preterm.

The Journal of pediatrics·2025

Same author

Higher electronic health record burden among women physicians in academic ambulatory medicine.

JAMIA open·2025

Search research articles

Related Experiment Video

Updated: Feb 5, 2026

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

Neonatal cerebrovascular autoregulation.

Christopher J Rhee¹, Cristine Sortica da Costa², Topun Austin²

¹Baylor College of Medicine, Texas Children's Hospital, Department of Pediatrics, Section of Neonatology, Houston, TX, USA. cjrhee@texaschildrens.org.

Pediatric Research

|September 10, 2018

Summary

This summary is machine-generated.

Neonatal cerebrovascular pressure autoregulation maintains stable cerebral blood flow (CBF). Impaired autoregulation in infants increases brain injury risk, necessitating optimized monitoring and adjuvant therapies for better neurologic outcomes.

More Related Videos

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Published on: January 19, 2020

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Related Experiment Videos

Last Updated: Feb 5, 2026

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression

Published on: December 10, 2014

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Published on: January 19, 2020

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Area of Science:

Neonatal physiology
Neurology
Pediatric critical care

Background:

Cerebrovascular pressure autoregulation maintains constant cerebral blood flow (CBF) despite changes in cerebral perfusion pressure (CPP).
Cerebral vasoreactivity, involving vasoconstriction and vasodilation, is crucial for maintaining autoregulation during arterial blood pressure (ABP) fluctuations.
Impaired autoregulation is linked to increased risk of brain injury and neurological deficits, particularly in vulnerable neonatal populations.

Purpose of the Study:

To review the mechanisms of neonatal pressure autoregulation.
To discuss autoregulation monitoring techniques in neonates.
To highlight the importance of brain protection strategies by optimizing autoregulation.

Main Methods:

Review of existing literature on neonatal cerebrovascular pressure autoregulation.
Discussion of physiological mechanisms including cerebral vasoreactivity.
Analysis of conditions impairing autoregulation in neonates, such as prematurity, HIE, IVH, congenital heart disease, and ECMO support.

Main Results:

Autoregulation is a critical protective mechanism for the brain.
Impairments in autoregulation are common in various neonatal disease states.
Both hypoperfusion and hyperperfusion can lead to significant neurological injury in infants due to their sensitivity to CBF changes.

Conclusions:

Current therapies are insufficient in preventing permanent brain injuries in neonates.
Adjuvant treatments aimed at supporting and optimizing cerebrovascular pressure autoregulation hold promise for improving neurologic outcomes.
Enhanced monitoring and therapeutic strategies are needed to protect the developing neonatal brain.