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Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma
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Alvimopan usage increasing following radical cystectomy.

Joshua D Belle1, Aydin Pooli2, Dimitry Oleynikov3

  • 1Division of Urologic Surgery, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Joshua.belle@unmc.edu.

World Journal of Urology
|September 10, 2018
PubMed
Summary
This summary is machine-generated.

Alvimopan use increased significantly after radical cystectomy, reducing patient perioperative morbidity. This study highlights the drug

Keywords:
AlvimopanBladder cancerCystectomyIleusVizient

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Area of Science:

  • Urology
  • Surgical Oncology
  • Pharmacology

Background:

  • Alvimopan (Entereg) is a peripherally acting opioid receptor antagonist.
  • It is approved for use after radical cystectomy (RC) to mitigate postoperative complications.
  • Previous studies demonstrated efficacy in colorectal surgery for postoperative ileus and hospital stay.

Purpose of the Study:

  • To assess the real-world utilization of alvimopan post-radical cystectomy.
  • To evaluate the impact of alvimopan on perioperative factors in RC patients.
  • To analyze trends in alvimopan use since its FDA approval for RC.

Main Methods:

  • Utilized data from the Vizient database (2014-2016).
  • Included patients who underwent radical cystectomy.
  • Collected data on alvimopan exposure and postoperative outcomes.

Main Results:

  • 7472 patients underwent cystectomy; 3391 (45.4%) received alvimopan.
  • Alvimopan utilization increased from 35% to 59% during the study period.
  • Alvimopan use was associated with decreased perioperative morbidity (10.53% vs 19.23%, p=0.027).

Conclusions:

  • Alvimopan utilization has substantially increased following FDA approval for radical cystectomy.
  • Increased alvimopan use is linked to reduced perioperative morbidity in RC patients.
  • This represents the largest study on real-world alvimopan utilization post-RC.