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Multimodal Optical Imaging Platform for Studying Cellular Metabolism

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Analytical Platforms and Techniques to Study Stem Cell Metabolism.

Christine Tang¹, Kevin Chen¹, Aleksandar Bajic^2,3

¹Department of Biosciences, Rice University, Houston, TX, USA.

Methods in Molecular Biology (Clifton, N.J.)

|September 10, 2018

Summary

This summary is machine-generated.

Metabolomics offers a snapshot of cellular health by analyzing metabolites. This chapter details methods, including mass spectrometry imaging, for studying stem cell metabolism for biomedical applications.

Keywords:

Mass spectrometry Mass spectrometry imaging Metabolomics Neural stem cells Nuclear magnetic resonance Stem cells

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Area of Science:

Systems biology
Metabolomics
Stem cell biology

Background:

Omics technologies provide deep biological insights.
Metabolomics analyzes the complete set of metabolites in a sample.
Stem cells possess complex, interacting molecular components.

Purpose of the Study:

To outline methods for studying stem cell metabolism.
To highlight the utility of metabolomics in understanding biological systems.
To encourage further research in stem cell metabolism.

Main Methods:

Utilizing metabolomics for a snapshot of biological status.
Employing mass spectrometry imaging.
Analyzing patterns of known and unknown analytes.

Main Results:

Metabolomics provides insights into biological conditions.
Mass spectrometry imaging is a key technology.
Understanding stem cell metabolism is crucial.

Conclusions:

Stem cell metabolism research is vital for physiological and pathological understanding.
This work aims to stimulate research in stem cell metabolism.
Applications span biomedical, pharmaceutical, nutritional, and clinical fields.