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Use of IMGT

Marie-Paule Lefranc1, François Ehrenmann2,3, Sofia Kossida2

  • 1IMGT®, The International ImMunoGeneTics Information System®, Laboratoire d'ImmunoGénétique Moléculaire (LIGM), Institut de Génétique Humaine (IGH), UMR 9002 CNRS-UM, Université de Montpellier, Montpellier Cedex 5, France. Marie-Paule.Lefranc@igh.cnrs.fr.

Methods in Molecular Biology (Clifton, N.J.)
|September 10, 2018
PubMed
Summary

IMGT® provides standardized immunoinformatics tools and databases for analyzing antibody and T cell receptor sequences and structures. This global reference system bridges the gap between antibody sequences and their 3D structures for engineering applications.

Keywords:
Antibody humanizationB cell epitopeC domainIMGTIMGT Collier de PerlesIMGT unique numberingIMGT-ONTOLOGYImmunoglobulinParatopeV domain

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Area of Science:

  • Immunoinformatics
  • Immunogenetics
  • Bioinformatics

Background:

  • IMGT® (international ImMunoGeneTics information system®) was established in 1989 to manage the vast diversity of antigen receptors.
  • Its creation marked the emergence of immunoinformatics at the intersection of immunogenetics and bioinformatics.
  • IMGT® provides standardized analysis of antibody sequences and structures, connecting them to their three-dimensional (3D) forms.

Purpose of the Study:

  • To highlight the IMGT® databases and tools for analyzing amino acid sequences, 2D, and 3D structures of immunoglobulins and T cell receptors.
  • To showcase IMGT®'s role as a global reference for immunogenetics and immunoinformatics.
  • To emphasize the utility of IMGT® standards in antibody engineering and humanization.

Main Methods:

  • Utilizing IMGT® Scientific chart rules based on IMGT-ONTOLOGY concepts: classification, description, and numerotation.
  • Employing IMGT® databases such as IMGT/LIGM-DB and IMGT/GENE-DB for nucleotide sequences and genes.
  • Leveraging tools like IMGT/V-QUEST, IMGT/JunctionAnalysis, IMGT/HighV-QUEST for sequence analysis, and IMGT/DomainGapAlign, IMGT Collier de Perles for structural analysis.

Main Results:

  • Standardized analysis bridges the gap between antibody sequences and 3D structures.
  • IMGT® databases (IMGT/2Dstructure-DB, IMGT/3Dstructure-DB) and tools (IMGT/DomainGapAlign, IMGT Collier de Perles) facilitate detailed structural analysis.
  • IMGT/mAb-DB offers an interface for monoclonal antibodies and related proteins, linking to WHO INN and structural databases.

Conclusions:

  • IMGT® is the global standard for immunogenetics and immunoinformatics.
  • Its comprehensive databases and tools are crucial for antibody engineering and humanization.
  • IMGT® provides essential resources for analyzing antibody and T cell receptor sequences and structures.