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Chemoenzymatic Defucosylation of Therapeutic Antibodies for Enhanced Effector Functions Using Bacterial α-Fucosidases

Chao Li1, Tiezheng Li1, Lai-Xi Wang2

  • 1Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA.

Methods in Molecular Biology (Clifton, N.J.)
|September 10, 2018
PubMed

Keywords:
ADCCChemoenzymatic synthesisDefucosylationGlycoengineeringTherapeutic antibodyTransglycosylationα-Fucosidase

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