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Inhibitory Effect of Standardized

Kyo Eun Kook1, Changhee Kim1, Wonku Kang2

  • 1Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.

Journal of Microbiology and Biotechnology
|September 10, 2018
PubMed
Summary

Java turmeric extract (CXS) effectively treats periodontitis by reducing inflammation and promoting bone repair. This study shows CXS inhibits key inflammatory markers and improves bone remodeling in an animal model, offering a natural therapeutic approach.

Keywords:
Curcuma xanthorrhizaosteoblastogenesisosteoclastogenesisperiodontal inflammationperiodontitis

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Area of Science:

  • Periodontology
  • Pharmacology
  • Biochemistry

Background:

  • Periodontitis is a severe inflammatory disease destroying gingival tissue and alveolar bone.
  • Oral pathogens' endotoxins trigger inflammatory responses leading to tissue destruction.
  • Curcuma xanthorrhiza (Java turmeric) exhibits known antibacterial and anti-inflammatory properties.

Purpose of the Study:

  • To evaluate the inhibitory effect of Curcuma xanthorrhiza supercritical extract (CXS) on lipopolysaccharide (LPS)-induced periodontitis.
  • To assess CXS's impact on inflammatory markers and bone remodeling in an animal model.
  • To determine the efficacy of CXS standardized with xanthorrhizol.

Main Methods:

  • Periodontitis was induced in Sprague-Dawley rats via topical LPS injection.
  • CXS (30 and 100 mg·kg-1·day-1) was administered orally starting on day 12.
  • Histological analysis and molecular markers (MMPs, NF-κB, IL-1β, NFATc1, TRAP, cathepsin K, ALP, COLA1) were assessed.

Main Results:

  • CXS inhibited gingival tissue collapse by preventing cell infiltration.
  • CXS significantly downregulated matrix metalloproteases (MMPs) and inflammation markers (NF-κB, IL-1β).
  • CXS improved bone remodeling by downregulating osteoclastic factors (NFATc1, TRAP, cathepsin K) and upregulating osteoblast markers (ALP, COLA1).

Conclusions:

  • CXS effectively ameliorates periodontitis by suppressing inflammation.
  • CXS promotes beneficial bone remodeling, counteracting periodontal tissue destruction.
  • The findings support CXS as a potential therapeutic agent for periodontitis.