Related Experiment Video
Updated: Feb 5, 2026

A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
BRAFi/MEKi in patients with metastatic melanoma: predictive factors of complete response
Simone Ribero1, Ottavia Malavenda2, Paolo Fava1
1Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin, Italy.
Aim:
A survival benefit was demonstrated by dabrafenib + trametinib for metastatic BRAF-mutated melanoma patients. Best response is a strong prognostic marker for survival.
Patients & Methods:
The specific features associated with complete response (CR) were evaluated.
Results:
A total of 15/66 patients achieved CR. Median size of lesions was 3 cm (range: 0.5-10). Using that value as cut-off, the CR rate was 39.3% in patients with smaller lesions and 10.5% in patients with bigger size (p = 0.006). The clinical features associated with CR were the number of metastatic sites and the largest diameter of the biggest metastatic site.
Conclusion:
The number of the metastases and the diameter of the largest metastatic site are associated with a higher CR rate.
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