Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alpha-adrenoceptor responsiveness in the aged rat.

J R Docherty, L Hyland

    European Journal of Pharmacology
    |July 15, 1986
    PubMed
    Summary

    Aging significantly reduces alpha 2-adrenoceptor responses and noradrenaline uptake in rats. Vascular alpha 1-adrenoceptor function remains largely unchanged with age.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hepatic infarction, hematoma, and rupture in HELLP syndrome: support for a vasospastic hypothesis.

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2021
    Same author

    Investigation of gender differences in the cardiovascular actions of direct and indirect sympathomimetic stimulants including cathinone in the anaesthetized rat.

    Autonomic & autacoid pharmacology·2016
    Same author

    Effects of desipramine on prazosin potency at α1A- and α1D-adrenoceptors in rat vas deferens: implications for the α1L-adrenoceptor subclassification.

    European journal of pharmacology·2014
    Same author

    Prazosin has low potency at α1A-adrenoceptors and high potency at α1D -adrenoceptors in rat vas deferens.

    Autonomic & autacoid pharmacology·2013
    Same author

    Influence of ketanserin on the effects of methylenedioxymethamphetamine on body temperature in the mouse.

    Autonomic & autacoid pharmacology·2013
    Same author

    The role of monoamines in the changes in body temperature induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and its derivatives.

    British journal of pharmacology·2010

    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology
    • Aging Research

    Background:

    • Vascular adrenoceptors play critical roles in blood pressure regulation.
    • Age-related changes in adrenergic signaling can impact cardiovascular health.
    • Understanding these changes is crucial for managing age-associated conditions.

    Purpose of the Study:

    • To investigate the impact of aging on vascular alpha 1- and alpha 2-adrenoceptor function in Sprague-Dawley rats.
    • To determine how aging affects the pressor and cardioinhibitory responses mediated by these receptors.
    • To assess the role of neuronal noradrenaline uptake in age-related cardiovascular changes.

    Main Methods:

    • Used anesthetized and pithed young and old Sprague-Dawley rats.
    • Administered alpha 1- and alpha 2-adrenoceptor agonists (amidephrine, xylazine) and noradrenaline (NA).
    • Utilized cocaine and prazosin to investigate neuronal uptake and alpha 1-adrenoceptor blockade.

    Main Results:

    • Old rats showed significantly reduced pressor and cardioinhibitory responses to the alpha 2-agonist xylazine.
    • Pressor responses to the alpha 1-agonist amidephrine were not significantly altered by aging.
    • Neuronal uptake of NA was reduced in old rats, as evidenced by altered responses to cocaine and prazosin.

    Conclusions:

    • Aging leads to diminished alpha 2-adrenoceptor-mediated vascular and cardiac responsiveness.
    • Neuronal noradrenaline reuptake is impaired in aged rats.
    • Vascular alpha 1-adrenoceptor function shows minimal alteration with age, suggesting selective adrenoceptor changes.

    Related Experiment Videos