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Two new C

Dan Zhao1, Shan-Shan Su2, Shao-Fei Chen1

  • 1Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

Chinese Journal of Natural Medicines
|September 11, 2018
PubMed
Summary
This summary is machine-generated.

Researchers identified new C21 steroidal glycosides, komaroside P and Q, from Cynanchum komarovii. These compounds, along with known ones, demonstrated significant inhibitory activity against human leukemia (HL-60) cells.

Keywords:
C(21) steroidal glycosidesCynanchum komaroviiCytotoxic activity

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology

Background:

  • Cynanchum plants are a source of bioactive steroidal glycosides.
  • Investigating novel compounds from this genus can lead to new therapeutic agents.

Purpose of the Study:

  • To isolate and characterize new C21 steroidal glycosides from Cynanchum komarovii.
  • To evaluate the cytotoxic activity of isolated compounds against human leukemia cell lines.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation via 1D, 2D NMR spectroscopy and acid hydrolysis.
  • In vitro cytotoxic assay against HL-60 cells.

Main Results:

  • Two new steroidal glycosides, komaroside P (1) and komaroside Q (2), were identified.
  • Three known compounds (3-5) were also isolated.
  • All five compounds exhibited potent inhibitory activity against HL-60 cells, with IC50 values ranging from 16.6 to 26.3 μmol·L-1.

Conclusions:

  • The study successfully identified novel steroidal glycosides from Cynanchum komarovii.
  • The isolated compounds show promising anti-leukemia activity, warranting further investigation.