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Updated: Feb 5, 2026

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[Research progress of long noncoding RNA in regulating adipogenesis].

Haoneng Tang1, Yaru Chen2, Houde Zhou2

  • 1Institute of Metabolism and Endocrinology; Hunan Key Laboratory for Metabolic Bone Disease; National Clinical Research Center for Metabolic Diseases; Department of Laboratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
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Summary

Long noncoding RNAs (lncRNAs) are key regulators of gene expression, impacting human disease development. This review highlights lncRNA roles in obesity, focusing on adipogenesis and energy metabolism.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Endocrinology

Background:

  • Long noncoding RNAs (lncRNAs) were initially dismissed as transcriptional noise but are now recognized for crucial regulatory roles in biological processes.
  • Recent research indicates lncRNAs are pivotal in regulating gene expression, influencing the development of various human diseases.
  • The growing prevalence of obesity necessitates exploring novel molecular mechanisms, including the role of noncoding RNAs.

Purpose of the Study:

  • To review recent advancements in understanding the role of lncRNAs in the pathogenesis of obesity.
  • To provide insights into how lncRNAs regulate adipogenesis and energy metabolism.

Main Methods:

  • Literature review of recent studies on lncRNAs and obesity.
  • Analysis of lncRNA functions, including RNA-RNA, RNA-DNA, and RNA-protein interactions.
  • Examination of lncRNA involvement in epigenetic, transcriptional, and post-transcriptional gene regulation.

Main Results:

  • Several lncRNAs have been identified as significant regulators of adipogenesis in both white and brown adipose tissues.
  • lncRNAs are implicated in modulating energy metabolism pathways relevant to obesity.
  • lncRNA interactions contribute to gene expression changes through diverse regulatory mechanisms.

Conclusions:

  • lncRNAs represent a significant area of research for understanding obesity mechanisms.
  • Further investigation into lncRNA functions may reveal novel therapeutic targets for obesity and related metabolic disorders.