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Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients

Xue-Qiang Guan1, Yang-Jing Xue2, Jie Wang2

  • 1Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China, wusaizhu_nfdx@163.com.

Clinical Interventions in Aging
|September 11, 2018
PubMed

Insights

Low bone mineral density (BMD) in the hip is linked to more severe coronary artery disease (CAD). This finding suggests a connection between bone health and heart disease risk in patients with chest pain.

Area of Science:

  • Cardiovascular Medicine
  • Osteoporosis Research
  • Radiology

Background:

  • Accelerated atherosclerosis is a proposed link between low bone mineral density (BMD) and cardiovascular events.
  • Existing coronary angiographic studies present conflicting evidence regarding the association between BMD and coronary atherosclerosis.

Purpose of the Study:

  • To comprehensively investigate the relationship between BMD and angiographically determined coronary atherosclerotic burden.
  • To clarify the association between BMD and the extent of coronary artery disease (CAD).

Main Methods:

  • A cohort of 459 patients with suspected coronary artery disease (CAD) underwent dual-energy X-ray absorptiometry and coronary angiography.
  • Analysis focused on the association between BMD and global coronary atherosclerotic plaque burden, including multivessel involvement and modified Gensini score.

Main Results:

  • Low BMD at the femoral neck and total hip independently correlated with multivessel CAD.
  • Negative independent associations were found between hip and femoral neck T-scores and the modified Gensini score.
  • No significant inverse correlation between BMD and CAD was observed at the lumbar spine.

Conclusions:

  • A significant inverse relationship exists between hip BMD and the modified Gensini score.
  • Low hip BMD (T-scores) is independently associated with an increased risk of multivessel coronary disease in patients presenting with stable chest pain.
Abstract

Keywords:
bone mineral densitycoronary artery diseaseglobal coronary atherosclerotic plaque burdenmodified Gensini score

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