Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.0K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

202
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
202
Liver Histology01:27

Liver Histology

4.4K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
4.4K
Liver Physiology01:30

Liver Physiology

3.8K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.8K
Liver Regeneration01:24

Liver Regeneration

4.4K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.4K
Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

2.1K
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative effects of low-level laser acupuncture and dry needling on clinical and functional outcomes in patients with chronic cervical myofascial pain syndrome: a randomized controlled trial.

Lasers in medical science·2026
Same author

Evaluating performance of non-invasive tests for fibrosis detection in MASLD with Type 2 Diabetes Mellitus: Insights from VCTE-Based assessment.

Clinics and research in hepatology and gastroenterology·2026
Same author

Efficacy and Safety of Asenapine in Bipolar Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Psychopharmacology bulletin·2026
Same author

Primary Intracranial DICER-1 Mutant Sarcoma: A Systematic Review of Existing Literature from 2000 to 2024.

Pakistan journal of medical sciences·2026
Same author

Correction to: Ultrasound Neuromodulation of an Anti-Inflammatory Pathway at the Spleen Improves Experimental Pulmonary Hypertension.

Circulation research·2026
Same author

Endoscopic Ultrasound With Fine Needle Biopsy Confirming a Diagnosis of Immune Checkpoint Inhibitor-Related Type 3 Autoimmune Pancreatitis.

Case reports in gastrointestinal medicine·2025

Related Experiment Video

Updated: Feb 5, 2026

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

4.0K

Liver function tests in identifying patients with liver disease.

Zohair Ahmed1, Umair Ahmed2, Saqib Walayat2

  • 1Department of Gastroenterology and Hepatology, University of Illinois, Chicago, IL, USA, Zahmed23@uic.edu.

Clinical and Experimental Gastroenterology
|September 11, 2018
PubMed
Summary

Routine laboratory tests show poor correlation with liver fibrosis stages in patients with chronic liver disease. Early identification of asymptomatic patients is crucial for timely treatment and improved outcomes.

Keywords:
HCVNAFLDchronic liver diseasecirrhosishepatic fibrosisserum markers

More Related Videos

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
09:51

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Published on: January 27, 2023

2.2K
Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

17.4K

Related Experiment Videos

Last Updated: Feb 5, 2026

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

4.0K
Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
09:51

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Published on: January 27, 2023

2.2K
Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

17.4K

Area of Science:

  • Hepatology
  • Clinical Biochemistry
  • Diagnostic Laboratory Medicine

Background:

  • Chronic liver disease (CLD) often presents with advanced cirrhosis or acute decompensation.
  • Liver function tests (LFTs) are commonly used for screening, but data linking them to fibrosis stages is limited.
  • Early detection of asymptomatic liver disease is vital for effective treatment and reduced mortality.

Purpose of the Study:

  • To investigate the correlation between routine laboratory values and biopsy-proven stages of hepatic fibrosis.
  • To determine if standard LFTs can accurately reflect the severity of liver fibrosis.

Main Methods:

  • Retrospective observational study of 771 liver biopsies.
  • Evaluation of serum markers including AST, ALT, INR, BUN, creatinine, platelets, alkaline phosphatase, bilirubin, and albumin.
  • Statistical analysis using mean, 95% confidence intervals, and multivariable generalized linear models.

Main Results:

  • Aspartate aminotransferase (AST) was significant only in advanced fibrosis stages (3 and 4).
  • Alanine aminotransferase (ALT) and albumin showed no statistical significance across fibrosis stages.
  • Platelets remained within normal limits, and INR was only significant in stage 4, near the upper normal limit.

Conclusions:

  • Routine laboratory values, including LFTs, demonstrate a poor correlation with the stage of liver fibrosis.
  • Asymptomatic patients may have normal or near-normal lab results, highlighting the need for increased clinical awareness.
  • Earlier identification strategies are essential to manage CLD burden and improve patient prognosis.