Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scientists' Warning to Humanity: Unnecessary Bureaucracy Is a Global Impediment to Productivity, Advancement of Human and Planetary Wellbeing, Science and Sustainability.

Microbial biotechnology·2026
Same author

Moonlighting in metabolism: bifunctional enzymes control nitrogen metabolism in <i>Bacillus subtilis</i>.

Microbiology and molecular biology reviews : MMBR·2026
Same author

Optimization and scale up of L-malic acid production from methanol by the methylotrophic yeast Ogataea polymorpha.

FEMS yeast research·2026
Same author

Social relevance of microbiology literacy.

FEMS microbiology letters·2026
Same author

Current Progress of Natural Product Export by Yeast.

Journal of agricultural and food chemistry·2026
Same author

Aerobic syngas conversion: opportunities, challenges, and solutions.

Current opinion in microbiology·2026
Same journal

Transcriptional regulatory network differences between six industrial <i>Escherichia coli</i> strains.

Metabolic engineering communications·2026
Same journal

Photosynthetic production of glutamine through metabolic analysis-based engineering of <i>Picosynechococcus</i> sp. PCC 7002.

Metabolic engineering communications·2026
Same journal

Metabolic engineering for tobacco quality improvement: Advances and perspectives.

Metabolic engineering communications·2026
Same journal

A yeast-based platform for etoposide production via yatein bioconversion.

Metabolic engineering communications·2026
Same journal

Utilization of phosphate-responsive promoters for auto-inducible management of biotechnological processes based on cyanobacteria.

Metabolic engineering communications·2026
Same journal

Effects of heterologous expression of glycolysis enzymes on product formation in <i>Clostridium thermocellum</i>.

Metabolic engineering communications·2026
See all related articles

Related Experiment Video

Updated: Feb 5, 2026

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
05:21

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

Published on: February 10, 2023

3.8K

CO

Ulf W Liebal1, Lars M Blank1, Birgitta E Ebert1

  • 1Institute of Applied Microbiology-iAMB, Aachen Biology and Biotechnology-ABBt, RWTH Aachen University, Worringer Weg 1, D-52074 Aachen, Germany.

Metabolic Engineering Communications
|September 11, 2018
PubMed
Summary
This summary is machine-generated.

Microbial conversion of carbon dioxide (CO2) to succinic acid shows promise for sustainable chemical production. While current processes are not competitive, optimization could lead to economically viable alternatives to sugar-based fermentation.

Keywords:
C1 carbon sourceCarbon fixationFlux Balance AnalysisMetabolic engineeringProfitabilitySuccinic acid

More Related Videos

Investigation of RNA Synthesis Using 5-Bromouridine Labelling and Immunoprecipitation
09:59

Investigation of RNA Synthesis Using 5-Bromouridine Labelling and Immunoprecipitation

Published on: May 3, 2018

9.9K
A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research
08:17

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

15.4K

Related Experiment Videos

Last Updated: Feb 5, 2026

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
05:21

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

Published on: February 10, 2023

3.8K
Investigation of RNA Synthesis Using 5-Bromouridine Labelling and Immunoprecipitation
09:59

Investigation of RNA Synthesis Using 5-Bromouridine Labelling and Immunoprecipitation

Published on: May 3, 2018

9.9K
A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research
08:17

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

15.4K

Area of Science:

  • Biotechnology
  • Metabolic Engineering
  • Sustainable Chemistry

Background:

  • Microbial carbon dioxide assimilation offers a sustainable route to chemical platform molecules.
  • Various natural and synthetic CO2 fixation pathways exist, necessitating early performance assessment.

Purpose of the Study:

  • To evaluate different microbial and synthetic pathways for converting C1 compounds to succinic acid using stoichiometric metabolic modeling.
  • To assess the economic feasibility and industrial applicability of these CO2 conversion processes.

Main Methods:

  • Stoichiometric metabolic modeling was applied using physiological and process data.
  • Computational analysis of cyanobacteria, acetogens, methylotrophs, and synthetic pathways in Saccharomyces cerevisiae.
  • Evaluation of production rates, product yields, and optimization potential.

Main Results:

  • No simulated microbial succinate production process, using reported data, achieved competitive production levels.
  • Key limitations identified were gas/photon transfer and metabolic activity, not metabolic network structure.
  • Optimized simulations indicated economically interesting values for most process alternatives.

Conclusions:

  • Current microbial succinate production via CO2 conversion is not economically competitive.
  • Process optimization, particularly in gas/photon transfer and metabolic activity, is crucial for industrial viability.
  • Optimized CO2 fixation pathways present promising alternatives to traditional sugar-based fermentations for succinic acid production.