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Related Experiment Video

Updated: Feb 5, 2026

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

Published on: March 15, 2019

Genome sequence analysis of

Zahid Ur Rehman¹, Intikhab Alam², Allan Anthony Kamau²

¹Water Desalination and Reuse Center (WDRC), Saudi Arabia.

Biotechnology Reports (Amsterdam, Netherlands)

|September 11, 2018

Summary

This summary is machine-generated.

Researchers sequenced the genome of Zooshikella ganghwensis strain VG4, finding gene clusters for novel antimicrobial compounds. This discovery aids the search for new drugs to combat rising antimicrobial resistance.

Keywords:

Bioactive secondary metabolites NRP Nonribosomal peptides PK Polyketides Zooshikella ganghwensis genome

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Last Updated: Feb 5, 2026

Ultra-long Read Sequencing for Whole Genomic DNA Analysis

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Published on: March 15, 2019

Novel Sequence Discovery by Subtractive Genomics

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Published on: January 25, 2019

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

Area of Science:

Microbiology
Genomics
Drug Discovery

Background:

Antimicrobial resistance (AMR) is a growing global health threat, necessitating the discovery of new antimicrobial agents.
Novel structural scaffolds are crucial for developing new drugs to overcome existing resistance mechanisms.

Purpose of the Study:

To present the draft genome sequence of Zooshikella ganghwensis strain VG4, an organism producing antimicrobial metabolites.
To identify potential biosynthetic gene clusters responsible for producing these bioactive compounds.

Main Methods:

Genome sequencing of Zooshikella ganghwensis strain VG4.
Bioinformatic analysis to identify secondary metabolite gene clusters (polyketide synthases, nonribosomal peptide synthetases).
In-silico prediction of metabolite structures.

Main Results:

The draft genome sequence of Zooshikella ganghwensis strain VG4 was successfully generated.
At least five gene clusters with the potential for synthesizing bioactive secondary metabolites were identified.
In-silico methods were employed to predict the structures of these potential metabolites.

Conclusions:

Zooshikella ganghwensis strain VG4 is a promising source for novel antimicrobial compounds.
Genomic analysis provides a roadmap for isolating and characterizing new bioactive secondary metabolites.
This study contributes to the pipeline for developing new antimicrobials against resistant pathogens.