Phytochemical screening and antioxidant parameters data in prostatic rats fed with

Area of Science:

• Phytomedicine
• Pharmacology
• Toxicology

Background:

• Traditional medicine extensively utilizes plants for therapeutic purposes.
• Benign prostatic hyperplasia (BPH) is a common condition in aging men, often managed with pharmaceutical interventions.
• Exploring natural compounds for BPH treatment is crucial for developing safer alternatives.

Purpose of the Study:

• To investigate the efficacy of hydro-ethanolic extract of Laportea aestuans (La) leaves in a rat model of benign prostatic hyperplasia (BPH).
• To evaluate the antioxidant parameters and phytochemical composition of La extract.
• To compare the effects of La extract with finasteride, a standard BPH treatment.

Main Methods:

• Benign prostatic hyperplasia (BPH) was induced in Wistar rats using testosterone propionate (TP).
• Animals were divided into groups receiving olive oil, BPH induction only, varying doses of La extract (100, 200, 400 mg/kg), or finasteride (5 mg/kg).
• Phytochemical screening and antioxidant parameters (superoxide dismutase, catalase, reduced glutathione) were assessed.

Main Results:

• The hydro-ethanolic extract of Laportea aestuans (La) contained saponins, flavonoids, alkaloids, phenols, tannins, and steroids.
• Administration of La extract at 400 mg/kg significantly increased antioxidant enzyme levels (superoxide dismutase, catalase, reduced glutathione) compared to the BPH-induced group.
• These antioxidant improvements suggest a protective effect against BPH-related oxidative stress.

Conclusions:

• Laportea aestuans (La) extract exhibits significant antioxidant activity.
• The phytochemical profile of La extract supports its traditional use and suggests potential as a therapeutic agent for benign prostatic hyperplasia (BPH).
• Further research is warranted to elucidate the specific mechanisms and clinical efficacy of La for BPH management.