Log D analysis using dynamic approach
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Updated: Feb 5, 2026

Evaluation of the Efficacy of Organic Peroxyacids for Eradicating Dairy Biofilms Using an Approach Combining Static and Dynamic Methods
Published on: December 9, 2022
Ganeshkumar Krishnamoorthy1, Prashanth Alluvada2, Esayas Alemayehu3
1Curtiss-Wright Avionics and Electronics, Dublin 14, Ireland.
Abstract:
Log D the logarithm ( log10 ) of the distribution coefficient ( D ), is one of the important parameters used in Lipinski's rule to assess the druggability of a molecule in pharmaceutical formulations. The distribution of a molecule between a hydrophobic organic phase and an aqueous buffer phase is influenced by the pH of the buffer system. In this work, we used both the conventional algebraic method and the generalized 'dynamic' approach to model the distribution coefficient of amphoteric, diamino-monoprotic molecule and monoprotic acid in the presence of salt or co-solvent. We have shown the equivalence of these methods by analysing the recently reported experimental data of amphoteric molecules such as nalidixic acid, mebendazole, benazepril and telmisartan.
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