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Quantum Dot-Based Probes for Labeling and Imaging of Cells that Express Matrix Metalloproteinases
David Benito-Alifonso1, Barbara Richichi2, Veronica Baldoneschi2
1School of Chemistry, University of Bristol, Cantock's Close, BS8 1TS Bristol, U.K.
Abstract:
The practical synthesis of novel multivalent fluorescent quantum-dot-based probes to target cellular matrix metalloproteinases (MMPs) (MT-MMPs) is reported. We show that these probes, which are decorated with a nanomolar water-soluble MMP inhibitor, can be used to label preferentially the surface of cancer cells that are known to express MMPs while no binding was observed on cells that do not.
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