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Correlations Between Cognitive Aspects and Quantitative EEG in Adults With Epilepsy
Gloria Maria Tedrus1, Leandro M Negreiros1, Raquel S Ballarim1
11 Pontificia Universidade Católica de Campinas (PUC-Campinas), Campinas, SP, Brazil.
Clinical EEG and Neuroscience
|September 11, 2018
Summary
Cognitive impairment is common in epilepsy patients. Quantitative EEG coherence measures are significantly associated with cognitive deficits, suggesting their potential as biomarkers for epilepsy-related cognitive alterations.
Area of Science:
- Neuroscience
- Epilepsy Research
- Cognitive Science
Background:
- Cognitive impairment is a frequent comorbidity in adult patients with epilepsy (PWE).
- The underlying pathophysiological mechanisms of cognitive deficits in PWE remain poorly understood.
- Quantitative EEG (QEEG) coherence offers a potential method to investigate brain network function in epilepsy.
Purpose of the Study:
- To assess cognitive functions in patients with epilepsy (PWE) compared to normal controls (NC).
- To investigate the correlations between quantitative EEG (QEEG) coherence and cognitive performance in PWE.
- To identify QEEG parameters associated with cognitive impairment in PWE.
Main Methods:
- Eighty PWE and 40 NC underwent neurological evaluation and a battery of cognitive tests, including Mini Mental State Examination, memory recall, verbal fluency (FAS and VF animals), and clock drawing.
- Quantitative EEG (QEEG) coherence was calculated for inter- and intrahemispheric connections across delta, theta, alpha, and beta frequency bands.
- Logistic regression analysis was employed to determine factors associated with cognitive impairment in PWE.
Main Results:
- PWE demonstrated significant impairments in phonemic verbal fluency (FAS) and delayed recall of figures compared to NC.
- PWE exhibited higher absolute power in all frequency bands and increased inter- and intrahemispheric beta coherence in the theta frequency.
- Logistic regression revealed significant associations between interhemispheric delta coherence and verbal fluency (VF animals) impairment, and between interhemispheric beta coherence and delayed recall impairment.
Conclusions:
- Patients with epilepsy exhibit significant cognitive impairment.
- Quantitative EEG (QEEG) coherence measures are significantly associated with specific cognitive deficits in PWE.
- QEEG coherence may serve as a valuable tool for understanding the pathophysiology of cognitive alterations in epilepsy and as a potential biomarker.
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