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Aging and Proteins: What Does Proteostasis Have to Do with Age?
S Magalhaes1,2, B J Goodfellow2, A Nunes1
1iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Current Molecular Medicine
|September 11, 2018
Summary
The global population is aging, making healthy aging crucial. This review explores how maintaining protein homeostasis (proteostasis) impacts aging and longevity, suggesting proteostasis components could be biomarkers for healthy aging.
Area of Science:
- Gerontology
- Molecular Biology
- Biochemistry
Background:
- Global life expectancy is increasing, necessitating a focus on healthy aging and disease prevention.
- Protein homeostasis (proteostasis) is vital for cellular function and is implicated in aging and age-associated diseases like Alzheimer's.
- Dysfunctional proteostasis is linked to aging, while improved proteostasis is observed in long-lived organisms.
Purpose of the Study:
- To review the characteristics of aging with a focus on proteostasis.
- To examine the impact of aging-related changes in proteostasis on lifespan in model organisms.
- To discuss the potential of proteostasis network components as biomarkers of healthy aging.
Main Methods:
- Literature review of aging characteristics and proteostasis mechanisms.
- Analysis of studies linking proteostasis components to lifespan in model organisms.
- Overview of current aging biomarkers and their limitations.
Main Results:
- Aging is associated with a loss of protein homeostasis.
- Modifications in proteostasis players significantly affect lifespan.
- Long-lived animals exhibit enhanced proteostasis.
Conclusions:
- Proteostasis is a key factor in the aging process and longevity.
- Components of the proteostasis network show promise as biomarkers for healthy aging.
- Further research into proteostasis could lead to interventions for age-associated diseases.
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