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Related Experiment Video

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Molecular characterization of

Asrar Elegail1, Nuha Yousif Ibrahim Mohamed1, Eman Osman Mohamed Nour1

  • 1National Tuberculosis Reference Laboratory, Khartoum, Sudan.

International Journal of Mycobacteriology
|September 11, 2018
PubMed
Summary

This study characterized drug resistance in Mycobacterium tuberculosis (MTB) strains from Sudan, finding Line Probe Assay (LPA) superior for multidrug-resistant TB (MDR-TB) detection. The CAS1_Delhi lineage was most prevalent.

Keywords:
Genotype lineagesSudanline probe assaypulmonary tuberculosisspoligotyping

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Molecular Epidemiology

Background:

  • Pulmonary tuberculosis (TB) remains a significant global health challenge.
  • Drug resistance in Mycobacterium tuberculosis (MTB) complicates treatment and control efforts.
  • Characterizing drug resistance profiles and circulating MTB lineages is crucial for effective TB management.

Purpose of the Study:

  • To determine the drug resistance patterns of MTB strains from pulmonary TB patients in Khartoum, Sudan.
  • To identify the specific lineages of MTB strains prevalent in the study population.
  • To compare the efficacy of different drug susceptibility testing (DST) methods.

Main Methods:

  • Sputom samples from 406 pulmonary TB patients were collected between 2007-2009.
  • Drug susceptibility testing (DST) was performed using the proportion method (PM) and Line Probe Assay (LPA).
  • Molecular epidemiology was conducted using Spoligotyping to determine MTB lineages.

Main Results:

  • Line Probe Assay (LPA) showed 100% agreement with PM for non-MDR strains and 62% for multidrug-resistant TB (MDR-TB) strains.
  • The CAS1_Delhi/family was the predominant MTB lineage, accounting for 52% of isolates.
  • No significant difference in lineages was observed between MDR and non-MDR strains.

Conclusions:

  • Line Probe Assay (LPA) offers advantages over the proportion method (PM) for early and accurate MDR-TB detection.
  • The CAS1_Delhi lineage is a major circulating strain in Khartoum, Sudan.
  • Understanding MTB lineages and resistance profiles is vital for targeted TB interventions.