Related Experiment Video
Updated: Feb 5, 2026
02:26
Intracranial Pharmacotherapy and Pain Assays in Rodents
Published on: April 9, 2019
5.9K
Current and emerging pharmacotherapy for prediabetes: are we moving forward?
Aisling Mangan1, Neil G Docherty1, Carel W Le Roux1,2
1a Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences , University College Dublin , Dublin , Ireland.
Expert Opinion on Pharmacotherapy
|September 11, 2018
Summary
Prediabetes, a precursor to type 2 diabetes, often goes undiagnosed. While lifestyle changes are key, metformin is the primary drug, though combination therapies are being explored for better outcomes.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Pharmacology
Background:
- Prediabetes is characterized by elevated blood glucose levels, falling short of a diabetes diagnosis.
- A significant majority (70%) of individuals with prediabetes progress to type 2 diabetes.
- Prediabetes is frequently underdiagnosed, limiting timely intervention.
Purpose of the Study:
- To review the pharmacological treatment of prediabetes.
- To explore strategies for preventing the progression from prediabetes to type 2 diabetes.
- To discuss emerging pharmacological therapies for prediabetes management.
Main Methods:
- A comprehensive literature search was conducted using PubMed and Embase.
- The review focused on randomized controlled trials investigating prediabetes treatments.
- Emerging pharmacological therapies with potential benefits were analyzed.
Main Results:
- Lifestyle intervention is the primary strategy for preventing diabetes progression.
- Metformin is established as the first-line pharmacological treatment for prediabetes.
- The additive benefit of combining metformin with lifestyle changes appears minimal.
Conclusions:
- Combination pharmacological approaches, with or without lifestyle interventions, warrant further investigation for additive benefits.
- Despite available evidence, the low penetrance of interventions is partly due to the prodromal nature of prediabetes.
- Further research into effective and accessible interventions for prediabetes is crucial.
More Related Videos
06:59A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
31.3K
04:05Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
Published on: June 30, 2023
2.9K
Related Concept Videos
01:26Psychosis: Goals of Pharmacotherapy
539
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
539
01:15Diabetes: Management and Pharmacotherapy
1.1K
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.1K
01:27Emerging Adulthood
700
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
700
01:30Introduction Cardiac Emergencies
373
Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
373
01:10Electrical Current
7.2K
Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
7.2K
01:29Applications of GIS: Disaster Management and Emergency Response
528
Geographic Information System (GIS) technology is essential for risk identification, action prioritization, and resource optimization in critical situations like flooding and earthquakes. By integrating spatial and demographic data, GIS provides a comprehensive framework for emergency response.GIS integrates data layers, like rainfall intensity, topography, elevation profiles, and river levels, to model high-risk flood zones. These layers assess areas susceptible to flooding based on their...
528