Face-to-trait inferences in patients with Parkinson's disease

Introduction: Parkinson's disease is a progressive neurological disorder characterized by the preferential loss of dopaminergic neurons in the substantia nigra, which project to the striatum. The disease is characterized by prominent motor symptoms, which are its cardinal features. Consequently, Parkinson's disease has been primarily considered a disorder of movement. However, increasing evidence has indicated that Parkinson's disease affects not only the motor domain but also the cognitive domain. Increasing evidence indicates that patients with Parkinson's disease have an impaired ability to recognize emotional facial expressions. Recent studies have reported that other socially relevant information from faces, including face-to-trait inferences for traits such as dominance, competence, and trustworthiness, may be processed in subcortical regions, including the amygdala and caudate nucleus. However, the mechanism underlying the processing of face-to-trait inferences for these traits in patients with Parkinson's disease is still unknown. This study aimed to assess the face-to-trait inference ability in patients with Parkinson's disease. Method: Face-to-trait inference ability was assessed using a forced-choice method in patients with Parkinson's disease and age- and sex-matched healthy controls. Results: Overall correct face-to-trait inferences occurred significantly less frequently in the Parkinson's disease group than in the control group. Further analysis revealed a significant interaction between groups and the extent to which facial features were exaggerated. Conclusions: The present results suggest that the sensitivity of face-to-trait processing was linear in the Parkinson's disease group but not in the healthy controls. These deficits may have resulted from dysfunction in subcortical regions, which may also lead to impairment in other social inferential abilities in patients with Parkinson's disease.