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Related Experiment Video

Updated: Feb 5, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
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Intrinsic cooperativity potentiates parallel

Trevor R Sorrells1,2, Amanda N Johnson3, Conor J Howard1,2

  • 1Department of Biochemistry and Biophysics, Tetrad Graduate Program, University of California, San Francisco, United States.

Elife
|September 11, 2018
PubMed
Summary
This summary is machine-generated.

Convergent evolution in fungi shows how transcription factors like Mcm1 and Rap1 can co-activate ribosomal protein genes. This shared mechanism explains parallel genetic changes across fungal lineages.

Keywords:
Kluyveromyces lactisS. cerevisiaechromosomesevolutionevolutionary biologygene expressiontranscription factors

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Area of Science:

  • Evolutionary biology
  • Molecular biology
  • Genetics

Background:

  • Convergent evolution offers insights into predictable evolutionary pathways.
  • Ribosomal protein genes in fungi independently acquired cis-regulatory sequences for the transcription regulator Mcm1.

Purpose of the Study:

  • To investigate the mechanism behind the convergent gain of Mcm1 cis-regulatory sequences in fungal lineages.
  • To understand how shared regulatory mechanisms drive parallel evolution.

Main Methods:

  • Comparative genomic analysis of fungal lineages.
  • Biochemical assays to study protein-DNA and protein-protein interactions.
  • Investigating the interaction between Mcm1, Rap1, and the general transcription factor TFIID.

Main Results:

  • Mcm1 and Rap1 share a conserved mechanism for transcriptional activation.
  • Both regulators cooperatively activate transcription via interactions with TFIID.
  • The shared interaction partner facilitates the channeling of mutations into functional regulatory sites.

Conclusions:

  • The intrinsic cooperativity between Mcm1 and Rap1 explains the parallel evolution of ribosomal protein gene regulation.
  • This mechanism accounts for the widespread fixation of hundreds of substitutions in independent fungal lineages.
  • Shared regulatory mechanisms can drive large-scale convergent genomic changes.