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Key miRNAs and target genes played roles in the development of clear cell renal cell carcinoma

Jianmin Liu, Beibei Liu, Yuanyuan Guo

    Cancer Biomarkers : Section a of Disease Markers
    |September 11, 2018
    PubMed
    Abstract

    Insights

    This study identified 52 differentially expressed microRNAs (miRNAs) and 2361 genes in clear cell renal cell carcinoma (CCRCC). Specific miRNA-gene pairs show prognostic value, offering potential biomarkers for this aggressive cancer.

    Area of Science:

    • Oncology
    • Genomics
    • Molecular Biology

    Background:

    • Clear cell renal cell carcinoma (CCRCC) represents the most aggressive subtype of renal cell carcinoma (RCC).
    • Understanding the molecular underpinnings of CCRCC is crucial for developing effective diagnostic and prognostic tools.

    Purpose of the Study:

    • To identify differentially expressed microRNAs (miRNAs) and their target genes in CCRCC.
    • To explore the potential of these molecular alterations as prognostic markers for CCRCC.

    Main Methods:

    • Utilized next-generation sequencing data for miRNA and mRNA from The Cancer Genome Atlas (TCGA) dataset.
    • Performed differential expression analysis, miRNA-mRNA correlation analysis, functional enrichment, and survival analysis.

    Main Results:

    • Identified 52 differentially expressed miRNAs and 2361 differentially expressed genes (DEGs) in CCRCC.
    • Revealed 89 significant inverse miRNA-mRNA pairs.
    • Found that specific miRNAs (e.g., hsa-mir-501) and their target genes (e.g., AK1, SLC25A15, PCDHGC3) possess significant prognostic value for CCRCC patients.

    Conclusions:

    • Alterations in differentially expressed miRNAs and their target genes are implicated in CCRCC development.
    • These molecular changes can serve as valuable prognostic markers for CCRCC.
    Keywords:
    Clear cell renal cell carcinomadifferentially expressed miRNAssurvivabilitytargets

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