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Antigen-specific active immunotherapy for ovarian cancer
Sterre T Paijens1, Ninke Leffers, Toos Daemen
1Obstetrics & Gynaecology, University Medical Center Groningen (UMCG), Groningen, Netherlands, 9713 GZ.
The Cochrane Database of Systematic Reviews
|September 11, 2018
Summary
Antigen-specific active immunotherapy shows promising immune responses in ovarian cancer but lacks clinical efficacy. Further research is needed due to inconsistent study reporting and risk of bias.
Area of Science:
- Oncology
- Immunotherapy
- Cancer Research
Background:
- Ovarian cancer prognosis remains poor despite chemotherapy advancements.
- Antigen-specific active immunotherapy aims to stimulate anti-tumour immune responses.
- This review is an update of previous analyses published in 2010 and 2014.
Purpose of the Study:
- To assess the clinical efficacy of antigen-specific active immunotherapy for ovarian cancer.
- To evaluate tumour response, post-immunotherapy treatment outcomes, and survival differences.
- To identify optimal immunotherapeutic strategies and tumour antigen combinations.
Main Methods:
- Systematic search of multiple databases and clinical trial registries up to July 2017.
- Inclusion of randomised controlled trials (RCTs) and non-randomised studies (NRSs).
- Data extraction and risk of bias assessment for included studies.
Main Results:
- Included 67 studies with 3632 women; significant heterogeneity in study conduct and reporting.
- CA-125-targeted antibody therapy showed no clinical benefit in large RCTs, despite immune response induction.
- Evidence quality for most outcomes was very low, except for survival (high-certainty).
Conclusions:
- No clinically effective antigen-specific active immunotherapy is currently available for ovarian cancer.
- Results must be interpreted cautiously due to significant limitations in study data and risk of bias assessment.
- Further large, well-designed RCTs are warranted to explore potential clinical efficacy.
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