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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
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Inductive Coupling and Flow for Increased NMR Sensitivity.

Guillaume Carret1, Thomas Berthelot1, Patrick Berthault1

  • 1NIMBE, CEA, CNRS, Paris-Saclay University, CEA Saclay , 91191 Gif-sur-Yvette , France.

Analytical Chemistry
|September 11, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces a novel device to boost Nuclear Magnetic Resonance (NMR) sensitivity for slowly relaxing nuclei using microfluidics and microcoil detection. The setup enhances sensitivity per time unit while integrating with commercial NMR systems.

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Area of Science:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Microfluidics
  • Analytical Chemistry

Background:

  • Enhancing NMR sensitivity is crucial for analyzing challenging samples, particularly those with slowly relaxing nuclei.
  • Previous methods required specialized setups, limiting broad applicability.
  • Integrating microfluidic devices with commercial NMR systems presents a significant technical hurdle.

Purpose of the Study:

  • To develop a novel device for enhancing NMR sensitivity in slowly relaxing nuclei.
  • To create a system easily adaptable to existing commercial NMR probeheads.
  • To achieve significant gains in sensitivity per unit time without compromising existing NMR capabilities.

Main Methods:

  • Utilizing controlled solution flow within a microfluidic circuit.
  • Employing microsized NMR detection with a microcoil.
  • Implementing inductive coupling between the commercial NMR antenna and the microcoil for seamless integration.

Main Results:

  • Demonstrated a significant gain in NMR sensitivity per unit time for slowly relaxing nuclei.
  • The proposed device is easily installed on any commercial NMR probehead.
  • The system preserves the full capabilities of the host NMR probehead.

Conclusions:

  • The developed device offers a practical and effective solution for enhancing NMR sensitivity.
  • This approach expands the applicability of NMR spectroscopy to a wider range of samples, especially those with slowly relaxing nuclei.
  • The integration method ensures compatibility with existing NMR infrastructure, promoting wider adoption.