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Updated: Feb 5, 2026
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Gastrointestinal Motility Monitor GIMM
Published on: December 1, 2010
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Gastroduodenal motility disorders.
Jan Tack1, K Van den Houte, Florencia Carbone
1Translational Research Center for Gastrointestinal Diseases (TARGID), University of Leuven, Leuven, Belgium.
Current Opinion in Gastroenterology
|September 11, 2018
Summary
This review covers recent advances in understanding and treating gastroduodenal motility disorders like functional dyspepsia and gastroparesis, highlighting new therapeutic options.
Area of Science:
- Gastroenterology
- Digestive Physiology
Background:
- Gastroduodenal motility disorders, including functional dyspepsia and gastroparesis, significantly impact patient quality of life.
- Understanding the underlying pathophysiology is crucial for developing effective treatments.
Purpose of the Study:
- To review recent advancements in the epidemiology, pathophysiology, and treatment of gastroduodenal motility disorders.
- To focus on functional dyspepsia and gastroparesis, providing insights into current research and clinical practice.
Main Methods:
- Comprehensive literature review of recent studies on gastroduodenal motility disorders.
- Analysis of pathophysiological findings, including cellular changes and immune activation.
- Evaluation of novel therapeutic agents and updated management guidelines.
Main Results:
- Pathophysiological research links delayed emptying and impaired accommodation to symptom patterns in these disorders.
- Functional dyspepsia shows altered duodenal mucosal integrity and low-grade immune activation.
- Gastroparesis exhibits changes in interstitial cells of Cajal and myenteric neurons.
- New treatments for gastroparesis include the prokinetic relamorelin and the antiemetic aprepitant.
- Neuromodulators show efficacy, and new management guidelines for functional dyspepsia have been published.
Conclusions:
- Recent research has elucidated key pathophysiological mechanisms in gastroduodenal motility disorders.
- Novel therapeutic strategies, including new prokinetics and neuromodulators, offer improved treatment options.
- Updated guidelines provide a framework for managing functional dyspepsia effectively.
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