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Adverse cutaneous reactions (ACRs) can occur with antipsychotics. This report details three cases of periorbital edema possibly linked to risperidone, highlighting the need for caution.

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Area of Science:

  • Psychiatry
  • Dermatology
  • Pharmacology

Background:

  • Antipsychotic medications are frequently prescribed for various psychiatric conditions.
  • Adverse cutaneous reactions (ACRs) are known side effects of antipsychotic use, affecting 2-3% of patients.
  • Periorbital edema is a rare but potentially distressing ACR.

Purpose of the Study:

  • To report three cases of periorbital edema potentially induced by risperidone.
  • To investigate the possible causal relationship between risperidone and periorbital edema.
  • To raise awareness among clinicians regarding this specific ACR associated with risperidone.

Main Methods:

  • Case series presentation of three patients experiencing periorbital edema.
  • Detailed clinical observation of symptom onset after risperidone initiation.
  • Assessment of symptom resolution upon discontinuation of risperidone.
  • Exclusion of other potential causes for periorbital edema.

Main Results:

  • Three patients developed periorbital edema after starting risperidone.
  • The edema resolved in all cases after risperidone was stopped.
  • No other systemic or local causes for the edema were identified.
  • This suggests a potential link between risperidone and periorbital edema.

Conclusions:

  • Risperidone may be associated with the development of periorbital edema.
  • Clinicians should be vigilant for ACRs, including periorbital edema, when prescribing risperidone.
  • Further research is warranted to confirm the association and understand the mechanism.