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Causes and prognosis of chronic intestinal pseudo-obstruction in 48 subjects: A 10-year retrospective case series

Wei Lu1, Yongtao Xiao, Jianhu Huang

  • 1Department of Pediatric Surgery, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai Institute for Pediatric Research Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.

Medicine
|September 12, 2018
PubMed

Insights

Chronic intestinal pseudo-obstruction (CIPO) in children has a poor prognosis, with a 39.6% mortality rate. Mycotic infections significantly increase mortality risk in pediatric CIPO patients.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Clinical Research

Background:

  • Chronic intestinal pseudo-obstruction (CIPO) is a severe condition affecting pediatric patients.
  • Delayed diagnosis often leads to multiple surgical interventions.
  • Understanding prognostic factors is crucial for improving outcomes.

Purpose of the Study:

  • To evaluate the prognosis and survival rates of pediatric CIPO patients.
  • To identify independent risk factors influencing CIPO prognosis.
  • To inform treatment strategies and improve patient survival.

Main Methods:

  • Retrospective case series analysis.
  • Inclusion of pediatric CIPO patients treated at Xinhua Hospital (2006-2016).
  • Statistical analysis to determine mortality-associated factors.

Main Results:

  • Overall mortality rate was 39.6% (19/48).
  • Mycotic infection was significantly associated with increased mortality.
  • Early onset (<1 year) and hypoganglionosis showed a tendency toward higher mortality.

Conclusions:

  • Pediatric CIPO carries a poor prognosis despite advancements in care.
  • Mycotic infections are a critical factor impacting mortality in pediatric CIPO.
  • Standardized criteria for surgical intervention may improve outcomes.

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