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Updated: Feb 5, 2026
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Published on: June 24, 2025
The association between urinary tract infection during pregnancy and preeclampsia: A meta-analysis
Ling Yan1, Yu Jin, Hongdong Hang
1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen Department of Obstetrics and Gynecology, No. 210 Hospital of PLA Department of Nephrology, The First Affiliated Hospital of Dalian Medical University Department of Obstetrics and Gynecology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Objective:
The association between urinary tract infection (UTI) during pregnancy and preeclampsia (PE) continues to be the subject of debate. This meta-analysis aimed to examine the relationship between UTI during pregnancy and PE.
Study Design:
Observational studies up to October 2017, extracted from Medline, PubMed, Cochrane Library, and Embase databases, were included in the analysis. Data were extracted to 4-fold table, and the pooled odds ratio (OR) and 95% confidence intervals (CIs) of respective studies were calculated. Then meta-analysis was performed.
Results:
Nineteen studies qualified the inclusion criteria. Urinary tract infection during pregnancy was found to be a risk factor for the development of PE (OR: 1.31, 95% CI: 1.22-1.40).
Conclusion:
Occurrence of UTI during pregnancy increases the risk of PE in pregnant women. Screening for, and treatment of UTI should be part of routine antenatal care, especially in developing countries.
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