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Updated: Feb 5, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Comorbidities and Complications in Idiopathic Pulmonary Fibrosis
Esteban Cano-Jiménez1, Fernanda Hernández González2, Guadalupe Bermudo Peloche3
1Hospital Universitario Lucus Augusti, Respiratory Department, 27002 Lugo, Spain. estebanmallorca@gmail.com.
Abstract:
Though idiopathic pulmonary fibrosis (IPF) is characterized by single-organ involvement, many comorbid conditions occur within other organ systems. Patients with IPF may present during evolution different complications and comorbidities that influence the prognosis and modify the natural course of their disease. In this chapter, we highlight common comorbid conditions encountered in IPF, discuss disease-specific diagnostic modalities, and review the current treatment data for several key comorbidities. The diagnosis and treatment of these comorbidities is a challenge for the pulmonologist specialized in interstitial lung diseases (ILDs). We will focus on pulmonary emphysema, lung cancer, gastroesophageal reflux, pulmonary hypertension, obstructive sleep apnea (sleep disorders), and acute exacerbation of IPF.
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