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Outcomes for Patients Aged 12-18 Months With Metastatic MYCN Non-Amplified Neuroblastoma and Unfavorable Biologic Features ("Mixed Biology Toddlers"): A Report From the International Neuroblastoma Risk Group (INRG) Project.

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Updated: Feb 5, 2026

Zebrafish Model of Neuroblastoma Metastasis
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Genetic Predisposition to Neuroblastoma.

Erin K Barr1,2, Mark A Applebaum3,4

  • 1Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA. ebarr1@peds.bsd.uchicago.edu.

Children (Basel, Switzerland)
|September 12, 2018
PubMed
Summary

Neuroblastoma, a common childhood cancer, has unknown initiating events. Recent genetic and genomic research is uncovering predisposing factors for both familial and sporadic neuroblastoma.

Keywords:
genome-wide association study (GWAS)germlineneuroblastomapredisposition

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Area of Science:

  • Pediatric Oncology
  • Cancer Genomics
  • Genetics

Background:

  • Neuroblastoma is the most frequent solid tumor in infants.
  • It causes a disproportionate number of pediatric cancer deaths.
  • Phenotypic heterogeneity impacts patient outcomes.

Purpose of the Study:

  • To review current knowledge of familial neuroblastoma.
  • To highlight germline variations linked to sporadic neuroblastoma.
  • To discuss future directions in neuroblastoma genomics and clinical applications.

Main Methods:

  • Review of existing literature on neuroblastoma genetics and genomics.
  • Analysis of germline variations associated with familial and sporadic disease.
  • Exploration of potential clinical applications of genomic findings.

Main Results:

  • Advances in genetics and genomics are elucidating neuroblastoma's genetic underpinnings.
  • Germline variations are identified as predisposing factors.
  • The interplay between tumor and host genetics is increasingly understood.

Conclusions:

  • Understanding neuroblastoma genetics is crucial for improving outcomes.
  • Genomic research offers potential for novel diagnostic and therapeutic strategies.
  • Further investigation into genetic predispositions is warranted.