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Related Experiment Videos

Metabolaid

Young-Sil Lee1, Won-Kyung Yang2, Hwa Yeon Kim3

  • 1Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Dajeon 34054, Korea. rheeys04@kiom.re.kr.

Nutrients
|September 12, 2018
PubMed
Summary

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This summary is machine-generated.

Metabolaid®, a blend of lemon verbena and hibiscus extracts, effectively reduced obesity and improved metabolic health in mice. This natural formula shows promise for managing weight and related conditions.

Area of Science:

  • Phytochemistry
  • Metabolic Health
  • Obesity Research

Background:

  • Lemon verbena (Lippia citriodora) and hibiscus flower (Hibiscus sabdariffa L.) possess traditional medicinal uses for various ailments.
  • Obesity is a growing global health concern with numerous complications, including metabolic dysfunction and inflammation.

Purpose of the Study:

  • To investigate the synergistic effects of Metabolaid® (MetA), a combination of lemon verbena and hibiscus extracts, on obesity and its associated complications.
  • To evaluate MetA's impact on body weight, adipose tissue, lipid profiles, glucose metabolism, and inflammatory markers in a high-fat-diet induced obesity mouse model.

Main Methods:

  • High-fat-diet (HFD) induced obese mice were treated with MetA.
  • Evaluated changes in body weight, white adipose tissue (WAT), liver weight, serum and hepatic lipid profiles, and glucose tolerance.
Keywords:
AMP-activated kinaseadipogenesishibiscushyperlipidemialemon verbenaobesitythermogenesis

Related Experiment Videos

  • Assessed appetite-regulating hormones (adiponectin, leptin) and inflammatory markers (TNF-α, IL-6).
  • Analyzed gene expression related to adipogenesis and thermogenesis in WAT, and AMPK phosphorylation and fatty-acid oxidation in the liver.

    • Main Results:

    • MetA significantly decreased body weight, WAT, and liver weight in HFD-induced obese mice.
    • Improved serum and hepatic lipid profiles, glucose tolerance, and enhanced cold-induced thermogenesis.
    • Modulated appetite hormones, increasing adiponectin and decreasing leptin.
    • Downregulated inflammatory factors (TNF-α, IL-6) and adipogenesis genes, while upregulating thermogenesis genes in WAT.
    • Increased AMPK phosphorylation and fatty-acid oxidation in the liver.

    Conclusions:

    • Metabolaid® effectively reduced obesity and its complications in a mouse model.
    • The formula demonstrates potential as a therapeutic agent for the prevention and treatment of obesity and related metabolic disorders.
    • Synergistic action of lemon verbena and hibiscus extracts contributes to MetA's beneficial effects.