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Dme-Hsa Disease Database (DHDD): Conserved Human Disease-Related miRNA and Their Targeting Genes in

Guanyun Wei1,2, Lianjie Sun3, Shijie Qin4

  • 1Laboratory for Comparative Genomics and Bioinformatics & Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Science, Nanjing Normal University, Nanjing 210046, Jiangsu, China. weiguanyun@gmail.com.

International Journal of Molecular Sciences
|September 12, 2018
PubMed

Insights

This study introduces DHDD, a novel database linking human disease-related microRNAs (miRNAs) and genes to their fruit fly (Drosophila melanogaster) counterparts. It aids research into disease mechanisms and potential therapies.

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • MicroRNA (miRNA) dysregulation is implicated in human diseases like cancer.
  • Understanding miRNA gene regulation is crucial for disease research.
  • Drosophila melanogaster serves as a valuable model organism for studying conserved biological mechanisms.

Purpose of the Study:

  • To create a comprehensive database (DHDD) of human disease-related miRNAs and their target genes conserved in Drosophila.
  • To facilitate the study of conserved gene regulatory networks in human diseases using a model organism.
  • To provide a resource for identifying orthologous genes and miRNAs across species.

Main Methods:

  • Collected human and Drosophila miRNA and disease-related gene data.
  • Identified orthologous miRNAs and genes using seed sequence mapping and the DRSC Integrative Ortholog Prediction Tool.
  • Determined miRNA-target gene relationships using miRTarBase, miRanda, and TargetScan.
  • Visualized interaction networks and signaling pathways.
  • Compiled data into the DHDD database.

Main Results:

  • Identified 136 human disease-related miRNAs orthologous to 83 Drosophila miRNAs.
  • Identified 677 human disease-related genes orthologous to 734 Drosophila genes.
  • Established miRNA-target gene interactions and conserved regulatory relationships.
  • Developed the DHDD database, a unique resource for cross-species disease gene research.

Conclusions:

  • The DHDD database is the first comprehensive collection of human disease-related miRNAs and target genes conserved in Drosophila.
  • DHDD enables efficient searching and visualization of conserved disease-related molecular mechanisms.
  • This resource supports research into human diseases by leveraging conserved pathways in a model organism.
Keywords:
Drosophila melanogasterdatabasediseasemiRNA

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