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[Two new flavonoid glycosides from leaves of Moringa oleifera]
Wei-Jian Ye1,2, Xiao-Jun Huang1,2, Chun-Lin Fan1,2
1Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
Abstract:
Two new flavonoid glycosides, quercetin-3-O-(4-O-crotonyl)-β-D-glucopyranoside (1) and quercetin-3-O-[6-O-(2E)-pentenoyl]-β-D-glucopyranoside (2), along with nine known ones, isoquercetin (3), astragalin (4), quercetin-3-O-(6-O-acetyl)-β-D-glucopyranoside (5), kaempferol-3-O-(6-O-acetyl)-β-D-glucopyranoside (6), quercetin-3-O-(6-O-crotonyl)-β-D-glucopyranoside (7), kaempferol-3-O-(6-O-crotonyl)-β-D-glucopyranoside (8), vitexin (9), isovitexin (10), and isorhamnetin-3-O-β-D-glucopyranoside (11), were isolated from the leaves of Moringa oleifera by various chromatographic technologies. Their structures were elucidated by spectroscopic methods including UV, IR, MS, and NMR. In addition, compounds 7 and 8 were isolated from this plant for the first time.
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Leaving Groups
In general, in a nucleophilic substitution reaction, a nucleophile displaces a functional group, called the leaving group, from the substrate to give a substituted product. A leaving group departs the substrate molecule through heterolytic cleavage, taking the pair of electrons with it to become a relatively stable weak base in the form of an anion or a neutral molecule.
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