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[Analysis on medication rules for treatment of dementia by ancient physicians based on data mining methods]
Ya-Qiao Yi1, Rui Fang2, Jin-Wen Ge1
1Hunan University of Chinese Medicine, Changsha 410208, China.
Summary
Ancient Chinese medicine records reveal key herbs and formulas for dementia treatment, focusing on replenishing Qi, invigorating the spleen, and nourishing the heart. These findings offer valuable insights for modern clinical practice.
Area of Science:
- Integrative and Complementary Medicine
- Traditional Chinese Medicine (TCM)
- Neuroscience and Neurology
Background:
- Dementia presents a growing global health challenge with limited effective treatments.
- Traditional Chinese Medicine (TCM) has a long history of treating cognitive disorders, including dementia.
- Systematic analysis of historical TCM prescriptions is needed to understand its therapeutic principles for dementia.
Purpose of the Study:
- To analyze the medication characteristics and prescription regularity of TCM for dementia based on historical medical records.
- To identify core herbal components and therapeutic strategies employed in ancient TCM dementia treatments.
- To provide evidence-based guidance for contemporary TCM clinical practice in managing dementia.
Main Methods:
- Retrieved ancient medical records on dementia treatment from authoritative Chinese medical texts (Han Dynasty to late Qing period).
- Established a normalized database of medical records for systematic analysis.
- Employed frequency statistics and association rule mining (Apriori, improved mutual information, entropy clustering) to analyze medication features and prescription rules.
Main Results:
- Analyzed 156 prescriptions involving 123 Chinese herbs with a total frequency of 11,747 instances.
- Identified frequently used herbs: Fuling, Yuanzhi, Renshen, Shichangpu, Gancao, Danggui, Maidong, Baizhu, Dihuang, and Ganjiang.
- Core prescriptions included Renshen, Fuling, Yuanzhi, Shichangpu, and Baizhu, with common strategies focusing on Qi-blood tonification, Yin-Yang regulation, and resuscitation.
Conclusions:
- Ancient TCM dementia treatments primarily emphasized Qi-replenishing, spleen-invigorating, and heart-nourishing strategies.
- Key therapeutic principles included nourishing Yin, enriching blood, eliminating phlegm, and warming Yang.
- The identified medication features and prescription rules offer valuable guidance for modern TCM dementia therapy.
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