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Related Concept Videos

Porin Insertion in the Outer Mitochondrial Membrane01:12

Porin Insertion in the Outer Mitochondrial Membrane

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Porins are beta-barrel proteins translocated to the mitochondrial outer membrane through the TOM complex into the intermembrane space. Porin precursors bind TIM chaperones within the intermembrane space and are guided to the Sorting and Assembly Machinery complex or SAM complex on the outer mitochondrial membrane.
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Chloroplast outer membrane proteins encoded by the nucleus are synthesized in the cytosol. Soon after synthesis, they bind cytosolic factors such as 14-3-3 protein and the Hsp70 chaperones that keep these precursors in an unfolded state until their translocation.
Two models describe the mechanism of precursor recognition and entry across the outer membrane through the TOC complex. Model 1 suggests the newly synthesized precursor binds to the TOC receptor 159 and forms a complex.
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The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
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Center of Gravity00:58

Center of Gravity

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The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...
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Center of Gravity01:15

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The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
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Center of Mass00:59

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The center of mass is the point at which the total mass of an object can be said to be concentrated. It is a fundamental principle in mechanics and physics that applies to all objects regardless of their shape or size. The center of gravity is the point at which an object’s weight appears to be concentrated and can be used to balance the object perfectly.
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Updated: Feb 5, 2026

Method for the Isolation of Francisella tularensis Outer Membranes
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Method for the Isolation of Francisella tularensis Outer Membranes

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The Outer Membrane Took Center Stage.

Volkmar Braun1

  • 1Department of Protein Evolution, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany;

Annual Review of Microbiology
|September 12, 2018
PubMed
Summary
This summary is machine-generated.

This research explores the outer membrane of Escherichia coli, focusing on protein import and iron regulation. Key findings reveal mechanisms for transporting toxins and iron chelates across this bacterial membrane.

Area of Science:

  • Molecular Biology
  • Bacterial Physiology
  • Biochemistry

Background:

Keywords:
autobiographylipoproteinouter membraneprotein toxinssurface signalingtransport

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  • The study of bacterial outer membranes, particularly in Escherichia coli, is crucial for understanding cellular processes.
  • Early work by Wolfhard Weidel on the murein layer and phage receptors laid the groundwork for outer membrane research.
  • The discovery of lipoprotein bound to murein highlighted the potential for unraveling outer membrane protein composition and function.