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Adaptive Radiotherapy Enabled by MRI Guidance.

A Hunt1, V N Hansen2, U Oelfke2

  • 1The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, London, UK.

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|September 12, 2018
PubMed
Summary
This summary is machine-generated.

Adaptive radiotherapy (ART) uses magnetic resonance imaging (MRI) to adjust cancer treatment plans in real-time. This MRI-guided approach enhances accuracy and personalizes radiation doses for better patient outcomes.

Keywords:
Adaptive radiotherapygatingimage guidedmagnetic resonance imagingradiotherapy planningtracking

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Area of Science:

  • Oncology
  • Medical Physics
  • Radiotherapy Technology

Background:

  • Standard radiotherapy plans are insufficient due to anatomical variations during treatment.
  • Accurate dose delivery requires monitoring and adapting to changes in target and surrounding tissues.
  • Existing X-ray imaging lacks soft-tissue contrast compared to MRI.

Purpose of the Study:

  • To review adaptive radiotherapy (ART) solutions enabled by magnetic resonance imaging (MRI) guidance.
  • To discuss the potential benefits of MRI-guided ART for various tumor types.
  • To explore the use of functional MRI for personalized geometric and biological adaptation.

Main Methods:

  • Discussion of adaptive radiotherapy (ART) principles.
  • Review of magnetic resonance imaging (MRI) technologies integrated with radiotherapy.
  • Exploration of functional MRI sequences for biomarker-informed adaptation.

Main Results:

  • MRI offers superior soft-tissue contrast without additional radiation.
  • Integrated MRI-radiotherapy platforms allow real-time motion monitoring.
  • Real-time imaging enables precise dose delivery with smaller treatment margins.
  • Functional MRI can facilitate personalized geometric and biological adaptation.

Conclusions:

  • MRI-guided adaptive radiotherapy (ART) enhances treatment accuracy and personalization.
  • This approach allows for individualized treatment margins and adaptive biological adjustments.
  • MRI-guided ART holds significant potential to improve patient outcomes across diverse tumor types.