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Dynamic expression of p75

Liqing Wang1, Chao Yu2, Xiaobo Sun3

  • 1Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.

Neuroscience Letters
|September 12, 2018
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Summary
This summary is machine-generated.

The low-affinity neurotrophic receptor (p75NTR) and Lingo-1 are present on mouse optic pathway axons. This finding supports the role of Nogo/NgR signaling in guiding optic axon divergence at the chiasm.

Keywords:
Axon guidanceLingo-1NgROptic chiasmVisual systemp75 (NTR)

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Nogo-NgR interaction on optic axons guides divergence at the mouse optic chiasm.
  • NgR requires co-receptors for signal transduction due to its lack of a cytoplasmic domain.

Purpose of the Study:

  • To investigate the localization of NgR co-receptors, p75NTR and Lingo-1, on axons within the developing mouse optic pathway.
  • To determine if p75NTR and Lingo-1 are present on optic axons, supporting Nogo/NgR signaling in axon divergence.

Main Methods:

  • Immunohistochemical analysis of mouse retinal and optic pathway tissues at various embryonic stages (E13-E15).
  • Detection of p75NTR and Lingo-1 expression on retinal ganglion cells, optic axons, and surrounding glial cells.

Main Results:

  • p75NTR and Lingo-1 were detected on retinal ganglion cells and optic axons in the retina, optic disc, optic stalk, optic chiasm, and optic tract.
  • p75NTR was observed on retinal axons at the optic disc.
  • Lingo-1 showed transient expression on chiasmatic neurons at E13 but was localized to glial processes surrounding axons at the optic disc.

Conclusions:

  • The presence of p75NTR and Lingo-1 on optic axons provides evidence for their involvement in the Nogo/NgR signaling pathway.
  • These findings strengthen the understanding of molecular mechanisms governing axon guidance and divergence at the optic chiasm.