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Progress in the development of olfactory-based bioelectronic chemosensors
John W Cave1, J Kenneth Wickiser2, Alexander N Mitropoulos3
1Department of Chemistry and Life Science, United States Military Academy, West Point, NY, United States; Burke Neurological Institute, White Plains, NY, United States; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States.
Biosensors & Bioelectronics
|September 12, 2018
Summary
This review explores artificial chemosensory devices, or bioelectronic sensors, inspired by animal olfaction. It examines biological materials and signal transduction systems used in their development, highlighting their effectiveness and future challenges.
Area of Science:
- Biotechnology
- Biosensors
- Nanotechnology
Background:
- Animal olfactory systems offer remarkable speed, sensitivity, and selectivity in chemical detection.
- Artificial chemosensory devices aim to replicate these natural capabilities for various applications.
- Bioelectronic sensors integrate biological components with signal transduction for chemical sensing.
Purpose of the Study:
- To review the incorporation of molecular and cellular components from natural olfactory systems into artificial chemosensors.
- To analyze the biological materials and signal transduction systems used in bioelectronic sensor development.
- To discuss the strengths, limitations, and effectiveness of current bioelectronic sensor designs.
Main Methods:
- Review of scientific literature on artificial chemosensory devices and bioelectronic sensors.
- Focus on studies integrating biological olfactory components with signal transduction systems.
- Analysis of reported data on sensor performance, strengths, and limitations.
Main Results:
- Various biological materials have been successfully combined with signal transduction systems to create artificial chemosensory devices.
- The effectiveness of different bioelectronic sensor designs varies based on the chosen biological material and transduction method.
- Key challenges remain in optimizing sensitivity, selectivity, and long-term stability.
Conclusions:
- Bioelectronic sensors hold significant promise for applications in industry, security, and medicine.
- Further research is needed to overcome limitations and advance the development of these sophisticated sensing technologies.
- Integrating biological olfactory mechanisms into artificial systems is a key strategy for future sensor innovation.
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