Therapeutic applications of zebrafish (Danio rerio) miRNAs linked with human diseases: A prospective review

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In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

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Manojit Bhattacharya1, Soumendu Ghosh2, Ramesh Chandra Malick1

  • 1ICAR-Central Inland Fisheries Research Institute, Barrackpore, Kolkata 700 120, West Bengal, India.

Gene
|September 12, 2018
PubMed

Insights

Zebrafish microRNAs (miRNAs) regulate cellular development and metabolism. This review explores their role in human diseases like cancer and diabetes, suggesting therapeutic inhibition strategies.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small, non-coding RNAs crucial for gene regulation.
  • Zebrafish are a key model organism for developmental biology and disease research.
  • Zebrafish miRNAs play roles in cellular development and metabolism.

Purpose of the Study:

  • To review the fundamental utilization of zebrafish microRNAs.
  • To explore their targeted regulation of human diseases.
  • To summarize cellular mechanisms and suggest therapeutic applications.

Main Methods:

  • Literature review of studies on zebrafish miRNAs and human diseases.
  • Analysis of molecular mechanisms underlying disease regulation by miRNAs.
  • Identification of potential therapeutic strategies targeting miRNA functions.

Main Results:

  • Zebrafish miRNAs are implicated in regulating cardiovascular disease, schizophrenia, cancer, and diabetes.
  • Specific miRNAs demonstrate regulatory roles at the molecular level in these conditions.
  • The zebrafish model facilitates understanding of disease-specific miRNA functions.

Conclusions:

  • Zebrafish miRNAs offer valuable insights into the molecular basis of human diseases.
  • Targeted inhibition of specific miRNAs presents a potential therapeutic avenue.
  • Further research in zebrafish can advance understanding and treatment of complex human disorders.
Keywords:
Disease modelHumanMicroRNAsTherapeuticsZebrafish

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