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An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos

Christopher R Gignoux1, Dara G Torgerson2, Maria Pino-Yanes3

  • 1Program in Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, San Francisco, Calif; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, Calif.

The Journal of Allergy and Clinical Immunology
|September 12, 2018
PubMed
Summary

Genetic ancestry analysis in Latinos revealed Native American ancestry increases asthma risk, while European ancestry offers protection. Decreased SMAD2 gene expression is linked to higher asthma risk and exacerbations.

Keywords:
AsthmaLatinosSMAD2admixture mappingasthma exacerbationsgene expressionmeta-analysisrare variationtargeted sequencing

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