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Quan Wen1,2, Shangbang Gao3, Mei Zhen4

  • 1Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, People's Republic of China qwen@ustc.edu.cn.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|September 12, 2018
PubMed
Summary

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This summary is machine-generated.

Central pattern generators in Caenorhabditis elegans motor neurons create rhythmic body movements. Proprioception and interneurons coordinate these oscillators for flexible forward and backward locomotion.

Area of Science:

  • Neuroscience
  • Computational Biology
  • Systems Biology

Background:

  • Motor rhythm generation is fundamental to locomotion.
  • Central pattern generators (CPGs) are neural circuits underlying rhythmic motor patterns.
  • Understanding C. elegans locomotion provides insights into general principles of sensorimotor systems.

Purpose of the Study:

  • To review and discuss recent findings on the origin of motor rhythm in Caenorhabditis elegans.
  • To elucidate the roles of motor neurons and premotor interneurons in generating and controlling body undulation.
  • To explore circuit-level functional compression in the C. elegans nervous system.

Main Methods:

  • Review of existing literature on C. elegans motor control.
  • Analysis of proposed mechanisms for intrinsic oscillation in motor neurons.
Keywords:
central pattern generatorsfunctional compressionmotor neuronneuromechanical modelprojection-premotor interneuronproprioception

Related Experiment Videos

  • Examination of the role of proprioception and interneuronal modulation.

    • Main Results:

    • A- and B-class motor neurons act as non-bursting intrinsic oscillators for forward and reversal movements, respectively.
    • Proprioception entrains motor neuron activity and facilitates directional undulation propagation.
    • Premotor interneurons modulate oscillations and couple motor neuron sub-circuits.

    Conclusions:

    • The C. elegans nervous system achieves complex sensorimotor functions through circuit-level compression.
    • A dynamic model integrating rhythm generation, proprioception, and descending regulation explains flexible locomotion.
    • C. elegans serves as a compact model for uncovering general principles of sensorimotor behaviors.