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Related Experiment Videos

Interspecies selective motoneuron projection patterns in chick-quail chimeras.

H Tanaka, L T Landmesser

    The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
    |October 1, 1986
    PubMed
    Summary

    Chick and quail motoneurons precisely innervate muscles across species, indicating conserved limb cues and neuronal guidance mechanisms essential for motor development.

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    Area of Science:

    • Developmental Biology
    • Neuroscience
    • Comparative Embryology

    Background:

    • Motoneurons guide muscle innervation during development.
    • Species-specific cues guide motoneuron projection.

    Purpose of the Study:

    • To investigate if chick and quail motoneurons can innervate the limb muscles of the opposite species.
    • To determine if limb-derived cues for motoneuron projection are conserved between chick and quail.

    Main Methods:

    • Chimeric embryos created by interchanging chick and quail limb buds.
    • Feulgen staining to confirm donor-origin tissue.
    • Electrophysiology and horseradish peroxidase (HRP) labeling to trace motoneuron innervation patterns.

    Main Results:

    • Motoneuron pools of one species selectively innervated homologous muscles in the limb of the opposite species.
    • Limb tissue was confirmed to be of donor origin, indicating completed muscle precursor cell migration.
    • A slight anterior shift in spinal segment innervation was observed in quail limbs compared to chick limbs.

    Conclusions:

    • Limb-derived cues for motoneuron guidance are highly conserved between chick and quail.
    • Motoneuron growth cones possess similar detection systems for navigating limb tissues.
    • This cross-species innervation highlights conserved principles in neural development and motor control.

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