Related Experiment Video

Updated: Feb 5, 2026

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization
06:01

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

7.1K

MiRNA Dysregulation in Childhood Hematological Cancer

Jaqueline Carvalho de Oliveira1, Gabriela Molinari Roberto2, Mirella Baroni3

  • 1Department Genetics, Federal University of Paraná, 80060-000 Paraná, Brazil. jaqbiomed@yahoo.com.br.

International Journal of Molecular Sciences
|September 12, 2018
PubMed

Insights

MicroRNAs (miRNAs) are key gene regulators implicated in pediatric leukemias and lymphomas. This review explores their roles and diagnostic potential in these childhood cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Traditional cancer biology research focused on protein-encoding genes.
  • MicroRNAs (miRNAs) are crucial regulators of gene expression in multicellular organisms.
  • Aberrant miRNA expression is linked to various pathological and malignant outcomes.

Purpose of the Study:

  • To review the roles of miRNAs in common pediatric leukemias and lymphomas.
  • To highlight the diagnostic and prognostic value of miRNAs in these cancers.

Main Methods:

  • Literature review of studies on miRNAs in pediatric leukemia and lymphoma.
  • Analysis of miRNA expression patterns and their correlation with disease characteristics.

Main Results:

  • MicroRNAs play significant roles in the development and progression of pediatric leukemias and lymphomas.
  • Specific miRNAs are associated with different subtypes and clinical outcomes.
  • MiRNAs show potential as biomarkers for diagnosis and prognosis.

Conclusions:

  • MicroRNAs are critical players in pediatric hematological malignancies.
  • Further research into miRNAs can lead to improved diagnostic and prognostic tools for childhood leukemia and lymphoma.
Keywords:
cancerchildrenleukemialymphomamiRNAreview

More Related Videos

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening08:14

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

16.2K
mirMachine: A One-Stop Shop for Plant miRNA Annotation06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

3.0K

Related Concept Videos

Erikson's Theory on Socioemotional Development during Childhood01:28

Erikson's Theory on Socioemotional Development during Childhood

Erik Erikson, a stage theorist, adapted Freud's theory to emphasize social factors in personality development throughout life, a concept known as psychosocial development. Unlike Freud, who focused on early childhood, Erikson believed that personality evolves across eight life stages, each marked by a specific challenge or "crisis." Successful resolution of each stage fosters competence, while failure may lead to feelings of inadequacy.
The first four of Erikson's eight...
1.1K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.2K
Piaget's Theory of Cognitive Development from Childhood into Adulthood01:25

Piaget's Theory of Cognitive Development from Childhood into Adulthood

Jean Piaget's theory of cognitive development emphasizes the role of thinking in a child's learning process, suggesting that children are naturally curious about their environment. His approach to development is discontinuous, proposing that cognitive abilities progress through distinct stages, each with unique characteristics. Central to Piaget's theory is schemata—mental structures that allow individuals to understand and interpret the world.
Schemata: Building Blocks of Knowledge
1.6K
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.4K
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.4K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K