Association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis: A systematic review and
Kazem Aghili1, Mohammad Reza Sobhan2, Masoud Mehdinezhad-Yazdi2
1Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Objective:
To assess the association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis (OA), a systematic review and meta-analysis was conducted.
Methods:
A total of 17 relevant case-control studies with 7424 cases and 11,310 controls was collected from several electronic databases up to June 2018.
Results:
The pooled results showed that GDF-5 rs143383 polymorphism was significantly associated with radiographic defined knee OA in overall and stratified analysis by ethnicity, source of controls and genotyping techniques.
Conclusions:
The GDF-5 rs143383 polymorphism might be used as a relevant risk estimate for radiographic defined Knee OA.
More Related Videos
Related Concept Videos
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
Knee Joint
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
5-Number Summary
In a box plot, the minimum and maximum data values represent the lower and upper whiskers in the graph, and the median is designated as the center of the box in the chart. The first quartile and third...
Random and Systematic Errors
Directing Effect of Substituents: meta-Directing Groups


