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Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures

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Published on: October 20, 2009

Back to Basics.

George E Guthrie¹

¹American College of Lifestyle Medicine, Chesterfield, Missouri.

American Journal of Lifestyle Medicine

|September 12, 2018

Summary

This summary is machine-generated.

Evidence-based non-drug therapies are crucial. A unified system is needed to evaluate both drug and lifestyle interventions using measures like Number Needed to Treat (NNT) and Number Needed to Harm (NNH).

Keywords:

bias evidence-based medicine lifestyle medicine non-drug therapy

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Published on: November 17, 2017

Area of Science:

Medical evidence evaluation
Comparative effectiveness research

Background:

Non-drug therapies are foundational but often rely on epidemiological evidence.
Drug therapies predominantly use randomized controlled trials (RCTs).
Current evidence appraisal systems have limitations in integrating diverse study types.

Purpose of the Study:

To advocate for evidence-based non-drug therapies.
To propose a unified system for evaluating medical evidence.
To incorporate common metrics for comparing interventions.

Main Methods:

Analysis of evidence strengths and weaknesses in epidemiological studies and RCTs.
Discussion of the need for integrated evidence appraisal.
Proposal of shared metrics like Number Needed to Treat (NNT) and Number Needed to Harm (NNH).

Main Results:

Epidemiological studies and RCTs possess distinct strengths and weaknesses.
A common measurement framework is necessary for robust evidence evaluation.
NNT and NNH can serve as unifying metrics.

Conclusions:

Non-drug therapies require robust, evidence-based integration into treatment plans.
A unified system is essential for evaluating diverse therapeutic evidence.
Implementing shared metrics like NNT and NNH will enhance comparative effectiveness and patient safety.