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Updated: Feb 5, 2026

Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase
Published on: March 19, 2020
Cobalt-catalyzed
Jiao-Na Han1, Cong Du1, Xinju Zhu1
1College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, People's Republic of China.
Abstract:
A cobalt-catalyzed C(sp2)-H alkoxylation of 1-naphthylamine derivatives has been disclosed, which represents an efficient approach to synthesize aryl ethers with broad functional group tolerance. It is noteworthy that secondary alcohols, such as hexafluoroisopropanol, isopropanol, isobutanol, and isopentanol, were well tolerated under the current catalytic system. Moreover, a series of biologically relevant fluorine-aryl ethers were easily obtained under mild reaction conditions after the removal of the directing group.
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