Synthesis and post-functionalization of alternate-linked-

Area of Science:

• Organic Chemistry
• Supramolecular Chemistry

Background:

• Thiacyclophanes are important host molecules in supramolecular chemistry.
• Research interest in novel synthetic procedures for thiacyclophanes has grown significantly.
• Thiacyclophanes are utilized for molecular recognition of organic compounds and metal ions.

Purpose of the Study:

• To report the selective and high-yielding synthesis of new alternate-linked-meta-para-thiacyclophanes.
• To demonstrate the successful post-functionalization of the phenolic moieties of these novel thiacyclophanes.
• To elucidate the three-dimensional structure of a specific thiacyclophane derivative.

Main Methods:

• Development of selective synthetic routes for thiacyclophanes.
• Application of post-functionalization techniques on phenolic groups.
• X-ray crystallographic analysis for structural determination.

Main Results:

• Achieved selective and high-yielding synthesis of novel alternate-linked-meta-para-thiacyclophanes.
• Successfully performed post-functionalization of the phenolic moieties.
• Determined the 3D structure of alternate-linked-meta-para-[22.12]thiacyclophane using X-ray crystallography.

Conclusions:

• The study presents efficient synthetic strategies for novel thiacyclophanes.
• The synthesized thiacyclophanes exhibit potential for diverse applications in molecular recognition.
• Structural characterization confirms the successful synthesis and architecture of the target compounds.