Related Experiment Video

Updated: Feb 5, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

9.6K

Gut Microbiota in Human Immunodeficiency Virus-Infected Individuals Linked to Coronary Heart Disease

Jan Kehrmann1, Jannis Menzel1, Mohammadkarim Saeedghalati2

  • 1Institute of Medical Microbiology, University Hospital Essen.

The Journal of Infectious Diseases
|September 12, 2018
PubMed

Insights

Human immunodeficiency virus (HIV) infection impacts gut microbiota diversity, influencing coronary heart disease (CHD) risk. Microbiome community structures, not just species, may aid CHD risk assessment in HIV patients.

Area of Science:

  • Microbiome research
  • Cardiovascular health in infectious diseases
  • Human virology

Background:

  • Human immunodeficiency virus (HIV) infection is a known risk factor for coronary heart disease (CHD).
  • HIV infection is associated with alterations in the gut microbiota composition and function.

Purpose of the Study:

  • To investigate the association between gut microbiota and coronary heart disease (CHD) in individuals with HIV.
  • To identify specific microbial patterns linked to CHD in the HIV-infected population.

Main Methods:

  • Analysis of gut microbiota composition in 60 HIV-infected individuals (30 with CHD, 30 without CHD).
  • Comparison of alpha-diversity, beta-diversity, and bacterial genus co-occurrence networks between groups.
  • Multidimensional scaling to identify distinct microbiome clusters.

Main Results:

  • Gut microbiota associated with CHD exhibited lower alpha-diversity.
  • Distinct co-occurrence networks of bacterial genera were observed between CHD+ and CHD- individuals.
  • Two microbiome clusters emerged, dominated by Prevotella or Bacteroides, with significant differences in 49 genera and distinct demographic profiles (e.g., sexual behavior).

Conclusions:

  • Gut microbiota community structures, rather than individual species, may be valuable for assessing CHD risk in HIV-infected individuals.
  • Sexual behavior is a significant factor influencing gut microbiota diversity and should be considered in future HIV-related CHD research.
Abstract

More Related Videos

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.9K
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

10.7K

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.4K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.1K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
480
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
276
Anatomy of the Heart01:27

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
119.9K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
531